Individuals with binge-eating disorder (BED), a highly prevalent condition in treatment-seeking individuals with obesity, exhibit recurrent binge eating and pronounced difficulty in the long-term maintenance of weight loss after behavioral weight loss (BWL) treatment. These difficulties are likely related to impairments in self-regulation, including a heightened reactivity to food, reduced inhibitory control, and increased reward sensitivity, which is reflected in differential neurophysiological activation in response to food cues in areas related to inhibitory control and reward. Addressing these underlying neurobehavioral difficulties could alleviate binge-eating symptomatology and enhance weight loss maintenance (WLM).
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