Animal Models in Obesity
The causes and impacts of obesity are manifold. The genetic analysis in humans is difficult due to the clinical variety, genetic heterogeneity, and the diverse environmental influences. In animal models the genetic heterogeneity and the variety of environmental factors can be minimized.
This is possible e. g. by specialized breeding (congenic mice). Certain genes can be deactivated (knockout). Genes that are associated with obesity can be detected (candidate genes). The metabolism, adipose tissue and hormones, or the impact of bariatric surgery can be examined in detail, as well as the mechanisms, which protect from obesity and its associated diseases.