Reset gut-dopamine axis as a cause of restored brain reward processing and sustained weight reduction following Roux-en-Y gastric bypass (RYGB) surgery (Dr. Wiebke Fenske)

In this research project eating behaviors and neuronal transmitters are being examined before and after bariatric surgery (gastric bypass RYGP). Obesity or bariatric surgery reduces the amount of food that can be eaten and digested due to a size reduction of the stomach and small intestine. These operations also seem to influence the perception of reward due to eating. The perception of reward is associated with the neuro transmitter dopamine. In obese patients often a hedonistic eating behavior can be observed - food is perceived more rewarding than in normal weight individuals.

. By neuro-imaging via positron-emission- and magnetic-resonance-tomography the function of dopamine in the brain, eating behavior and the perception of reward in bariatric patients before and after surgery is being additionally examined. This research can help to predict which patients will benefit from bariatric surgery.

Duration: 01.05.2015 – 31.10.2018

Project head

Dr. Wiebke Kristin Fenske

Head of research group "Neuroendocrine obesity research"
Former member: student career board
Head of project

+49 341 97-13306

wiebkekristin [dot] fenske [at] medizin [dot] uni-leipzig [dot] de