Longitudinal alterations in DNA methylation and association with obesity risk in children (Prof. Dr. Yvonne Böttcher)
Besides the genetic hereditary impact on the obesity risk of a person, epigenetic influences are assumed to play a role. Epigenetic influences on the human genotype are natural chemical processes influencing the DNA (methylation). This DNA-methylation can be modulated by environmental influences, yet methylation does not change the components of the genes (DNA), but it influences the gene function. Methylation can turn specific genes on or off. An early genetic and epigenetic prediction of the obesity risky could be useful for appropriate prevention measures in childhood. This study examines the epigenetic influence on specific areas of the DNA and their potential association with the adiposity risk in later childhood.
Moreover, the influence of age, gender and physical activity on this association will be clarified. Based on this data further research can follow whose insights will be useful for prevention and therapy programs.
Duration: 01.05.2015 – 30.04.2020
Description of research project
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