Identification and characterization of novel genes with neuronal and astrocytic influence on body weight regulation (Prof. Dr. Peter Kovacs)

In the development of obesity the brain, especially the hypothalamus, plays an important role - besides the adipose tissue. In this brain region energy consumption and eating is being coordinated. Recent studies have detected new obesity risk genes in the brain which influence the emergence of obesity. The complex interaction of certain brain and neuronal cells (neurons and astrocytes) imply the influence of diverse genes in the devel-opment and degree of obesity. The study therefore investigates via DNA-analyses the different impacts of obesity risk genes on neurons and astrocytes in normal- and overweight mice.

The final aim is to scrutinize the possible connection between the risk genes and eating behaviors as well as structural changes in the brain. This provides a better understanding of the brain’s role in the development of obesity especially with reference to energy metabolism (homeostasis) and eating behavior.

Duration: 01.05.2015 – 30.04.2020

Description of research project

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Head of project

Prof. Dr. Peter Kovacs

IFB-Professorship "Adiposity and diabetes genetics"
Member: internal board
Head of project

+49 341 97-15892

peter [dot] kovacs [at] medizin [dot] uni-leipzig [dot] de