Specific impact of hypothalamic G-protein-signaling cascades on appetite (Dr. Doreen Thor)

In order to find new ways to influence the regulation of appetite in humans, it is important to understand the underlying mechanisms. Here certain brain regions (neurons in the hypothalamus) are crucial, which regulate the energy balance (homeostasis) and the sensation of hunger. In this study special ways of neuronal signaling (signaling cascade) are being examined.

The examination of this very complex brain network is possible due to especially altered receptors (DREADD). In a genetically adapted (transgenic) mouse model researchers test the influence of special neuronal receptors (G-protein-coupled receptors) on energy homeostasis and appetite regulation. Also, genetic factors are being searched that influence these receptors. A better understanding of the neuronal mechanisms of appetite control could help to develop novel pharmaceuticals and to better predict and understand side-effects of present anorexiants.

Duration: 01.05.2015 – 31.12.2018

 

Head of project

Dr. rer. nat. Doreen Thor

Head of project

+49 341 97-22175

doreen [dot] thor [at] medizin [dot] uni-leipzig [dot] de