The role of autophagy in peripheral nervous system and in the adipose tissue of WOKW rats with the metabolic syndrome (Joanna Kosacka, PhD, completed)

This study examines in animal models how special metabolic diseases lead to a protecting mechanism against diabetes and peripheral neurodegeneration (nerve damage). Metabolic diseases like the metabolic syndrome normally lead to a higher prevalence of diabetes and neuro degeneration (peripheral neuropathy). This study examins, if the proliferation of immune cells such as macrophages and T-cells and an increased autophagy (degrading of cell components) in the peripheral neurons of the spinal ganglions or fat cells contribute to the protective mechanism. The research can be the basis for further human studies.

Duration: 01.11.2013 - 30.04.2015

 

Description of research project

text follows

Head of project

Kosacka, Joanna

PhD Joanna Kosacka

Head of project

+49 341 97- 22051

joanna [dot] kosacka [at] uniklinik-leipzig [dot] de