The role of macrophages in the secretion and physiology of the adipokine adipocyte fatty acid-binding protein (Prof. Dr. Mathias Fasshauer, completed)
The level of a specific fatty tissue hormone, the so-called Adipocyte Fatty Acid-Binding Protein (AFABP), is increased in the blood of obese people. This leads to a higher risk for type 2 diabetes, metabolic syndrome and arteriosclerosis. Besides fat cells also specific immune cells (macrophages) produce AFABP. This study examines for the first time, if AFABP is released actively by macrophages into the blood circulation and if circulating AFABP affects the function of macrophages. The researchers examine if AFABP emitted by macrophages contributes to metabolic or cardiovascular diseases and whether this may be a working point for future obesity therapies.
Duration: 01.07.2014 - 30.04.2015
Description of research project