The role of the kidney in adipokine physiology (Prof. Dr. Mathias Fasshauer)
The production and effect of various hormones of the adipose tissue (adipokines) is impaired in adiposity. This is often associated with diseases of the large blood vessels (atherosclerosis or macroangiopathy). It has not been examined yet, if the small blood vessels are also affected (microangiopathy). Among others, a micro-angiopathy leads to an aggravation of the kidney function – as often observed in type-2-diabetes. This study examines in animal models if the adipokine levels are increased in chronic or acute kidney weakness and if adipokines are discharged by the kidneys.
Likewise, it will be determined whether adipokines contribute to kidney impairment in obesity and diabetes. A special focus is on the adipokine „adipocyte fatty acid-binding protein“ (AFABP). For the first time, the interaction of AFABP and other dysfunctional adipokines on the one hand, and kidney function on the other hand is determined.
Duration: 01.05.2015 – 30.04.2020
Description of research project
Head of project