Role of environmental compounds and epigenetics in human adipose tissue dysfunction (ExpoEpiG) (Prof. Dr. Matthias Blüher, completed)
Persons with obesity often develop dysfunctions of the adipose tissue which affect health. Their adipose tissue contains enlarged fat cells, inflammation cells intrude into the fatty tissue and the visceral fat accumulates. The triggers for these dysfunctions are mostly unknown. Therefore, in this study it is being investigated, how pesticides and plasticizers in foods and in the environment get into the human adipose tissue and whether they contribute to the dysfunctions of the adipose tissue.
Samples of visceral and subcutaneous adipose tissue from obese study participants and from post bariatric patients are tested for environmental or food contaminations. Finally, the substances that affect the adipose tissue most will in-depth be tested in animal models. The aim of this research is to identify environmental and food contaminants which are potentially harmful, to add them onto the list of dangerous substances, and to ban their use e. g. in convenient foods and food packages.
Duration: 01.05.2015 – 31.10.2017
Description of research project
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