Losing weight is hard – but keeping it is harder! Understanding the central metabolic mechanisms of post-dieting weight regain and their modifications by Roux-en-Y gastric bypass surgery in a rodent model of diet-induced obesity (Dr. W. Fenske, compl.)
Most of the overweight people regain their lost kilos after a weight reduction within a year. Often they regain even formerly (yo-yo effect). After a surgical adiposity treatment there is no yo-yo effect. In the regulation of energy consumption and intake, the hormone leptin seems crucial. The researchers of this study examine how the effect of leptin and other hormones and the energy balance is different in the conservative and operative way of losing weight. The biological mechanisms are scrutinized which lead to a sustained weight loss.
Duration: 01.11.2013 - 30.04.2015
Description of research project