MetaSeminar: Hormonal regulation of human eating behavior: effects of leptin and of GLP-1-analogs on hunger centers in the brain

29.05.2018 - 15:00 bis 16:00
IFB AdipositasErkrankungen
Philipp-Rosenthal-Str. 27
Konferenzraum (2. OG)
04103 Leipzig
Öffentliche Veranstaltung - Keine Anmeldung notwendig

Speaker: Dr. Haiko Schlögl

Abstract: Human eating behavior is regulated by bodily hormones secreted in response to energy intake and by fat tissue, the energy storage of the body. These hormones act on brain circuits which regulate our drive to eat. To measure the effects of body hormones on the brain we performed functional magnetic resonance imaging (fMRI) in two different studies: in the first study we applied the anorexigenic GLP-1-analog exenatide to obese male participants and measured brain activity when participants rated pictures of food. In a second study we applied an analog of the adipocyte hormone leptin (i.e., metreleptin) to patients with the rare disease of lipodystrophy, which is characterized by a paucity of adipose tissue and low levels of endogenous leptin. In both studies we found significant changes of brain activity in regions which are involved in the regulation of human eating behavior. In both studies, those changes were accompanied by changes in eating behavior.