Imaging in adiposity

This IFB Core Unit provides all project partners of the IFB with the means to detect risk factors associated with obesity, mainly using Magnetic Resonance (MR) Technology.

Magnetresonanztomographie der Core Unit Bildgebung
Magnetic Resonanace Imaging (MRI) (Photo: Nicolas Linder)

Prof. Dr. Karl-Titus Hoffmann
Department of Diagnostic and Interventional Radiology
University Hospital, 04103 Leipzig, Germany

Duration: 01.05.2010 - 30.04.2020

Service and Tasks:

The Core Unit Imaging in Adiposity provides magnetic resonance technologies to perform morphological and functional measurements of obesity-related risk factors. These non-invasive measurements include volumetric analyses of visceral (VAT) and subcutaneous adipose tissue (SAT) depots, as well as characterization and quantification of liver and muscle fat.  The Core Unit Imaging in Adiposity also analyses MR data and supports collaborators in data interpretation. Other tasks are the continuous revision and optimization of imaging and evaluation methods, the support of planning upcoming studies within the IFB AdiposityDiseases, as well as the implementation of new methods.

Association with the clinical IFB-projects

  • BaroDiet Follow-up – Assessment of long-term effects after bariatric surgery. Comparison of two low-caloric diets.
    Prof. Arne Dietrich, Department of Visceral, Transplantation, Thorax and Vascular Surgery, Section Bariatric Surgery and PD Dr. Thomas Karlas, Department of Gastroenterology and Hepatology
  • GluMBSE – Glucose metabolism after bariatric surgery and guided exercise, Prof. Arne Dietrich
  • MetaCardis – The effect of the enteral microbiome on cardio-metabolic risk factors. Dr. Rima Chakaroun, Department of Endocrinology and Nephrology
  • MetaSurg – Comparison of different methods of bariatric operations with regard to cardio-metabolic risk factors, Prof. Arne Dietrich
  • PLIS – Lifestyle intervention study in pre-diabetic patients, Dr. Gesine Flehmig, Cooperation with the Institute for Diabetes Research and Metabolic Diseases (DZD), Tübingen
  • PREG – Prospective longitudinal study on gestational diabetes, Dr. Gesine Flehmig
  • Leptin-Study – Influence of the leptin metabolism on cardio-metabolic risk factors, Dr. Konstanze Miehle, Department of Endocrinology and Nephrology
    Final evaluation, measurements completed (10/2015)
  • ExpoEpiG – Role of environmental compounds and epigenetics in human adipose tissue dysfunction, Prof. Matthias Blüher, Department of Endocrinology and Nephrology, Forthcoming
  • STEN –  Long-term comparison of endurance and strength training for two years regarding effects on cardio-metabolic risk factors, Prof. Matthias Blüher
    Completed (9/2016)
  • NILS-R-CHD – Risk-assessment of patients with coronary heart disease through non-invasive liver screening, Dr. Sebastian Beer, Department of Gastroenterology and Hepatology, Completed (12/2016)

Our own studies

  •  Validation of MR-sequences for a precise lipid quantification
  • Establishing new software solutions to quantify fat-subcompartments
  • Assessing the precision and feasibility of quick estimations of visceral adipose tissues based on a selection of tomography images
  • Correlation between stages of adiposity or fatty liver disease and spatial measurements of the MR-relaxation time span (T1) in adipose tissue
  • MR Spectroscopy study of the composition of the visceral fat tissue
  • Quantifying surrogate parameters to evaluate sarcopenia and cachexia

Cooperation with clinical partners

  • Interaction between thyroid hormone and brown fat tissue (PD Dr. Anke Tönjes, Nuclear Medicine)
  • Retrospective correlation of postoperative complications after pancreaticoduodenectomy (Dr. Georg Wilterger, Surgery)
  • Correction of the standard uptake value in PET Imaging with the help of MRI detection of the fat-free body mass (Dr. Thies Jochimsen, Dr. Peter Werner, Nuclear Medicine)

Staff

Dr. rer. nat. Harald Busse, physicist, head of the working group
Dr. med. Nicolas Linder, resident physician
Roland Stange, engineer (FH)
Alexander Fuhrmann, medical radiographer

Contact:
Dr. rer. nat. Harald Busse
Tel.:     +49 (341) 97-17413
Fax:     +49 (341) 97-17409
E-Mail: harald [dot] busse [at] medizin [dot] uni-leipzig [dot] de

Dr. med. Nicolas Linder
Tel.:     +49 (341) 97-17460
Fax:     +49 (341) 97-17409
E-Mail: nicolas [dot] linder [at] medizin [dot] uni-leipzig [dot] de