Clinical trials

Various clinical studies run at the IFB AdiposityDiseases. A clinical trial is being realized controlled and systematically analyzed on a large number of patients or healthy study participants. Thus it is possible to evaluate the success of new therapies, pharmaceuticals or medical devices impartial. Through the results of clinical trials doctors gain a greater confidence in dealing with new methods of treatment.

Every clinical trial has to be previously examined and assessed regarding its safety for the patients by an ethical review committee. Studies that apply pharmaceuticals or medical devices must also be approved by the responsible higher federal authority.

A controlled study compares two or more groups of patients. Patients of the so-called “intervention group” receive e.g. a new treatment method and the control group receives an alternative treatment. This comparison is important to find out the real effect of a treatment.

To obtain reliable results, it is also necessary to restrict external factors influencing the study results as far as possible or better yet to exclude them. This can be e.g. the age, gender or physical condition of the patient. Through a random allocation of the study participants to the treatment groups can be achieved that these factors are evenly spread among the groups. Thus, the same initial conditions exist within the groups.

Moreover, there are studies in which only certain medical facts are observed and documented. Such studies are called non-interventional or observational studies. Based on such studies e.g. information on the incidence or prognosis of diseases can be obtained.

Clinical trials take place in the following research areas of the IFB:

Fettzellen

Hormones

Different hormones, so called adipokines, are produced in fat cells (adipocytes). These adipokines influence amongst others the human metabolism. Thus, the fat tissue is more than an energy depot.

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adipöse Kinder - Jugendliche

Obesity in children

Severe overweight in children or adolescents means a high risk for adiposity in adulthood. Already young patients can develop the diseases associated with obesity, such as type-2-diabetes.

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Adipositas Chirurgie

Obesity surgery

Obesity or bariatric surgery has gained acceptance in the previous years. The number of operations has grown strongly. The IFB examins the operation methods and their effects scientifically.

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PET Neurobildgebung Gehirn

Neuro imaging

Modern imaging methods like positron emission tomography allow the exact depiction of brain structures and functions, as well as of the distribution and amount of neuro transmitters such as dopamine.

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psychosoz. Adipositas Aspekte

Psychosocial aspects

Psychosocial aspects like the living and working conditions, education, family, and social contacts are important for the emergence and the perpetuation of adiposity and its associated diseases.

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